DEVELOPMENT OF THE RADIOISOTOPE PRODUCTION TECHNOLOGIES AT THE WWR-M RESEARCH REACTOR
Abstract
The technological cycle was developed for the 99mTc-pertechnetate radiopharmaceutical (Na99mTcO4 solution) by means of nuclear reactions 98Mo(n,g)99Mo. The description of the technological line on the WWR-M reactor and the hot-cells for the radionuclide generation and fabrication of the radioisotope production is presented. The scheme of centralized extraction generator is used for the radiopharmaceutical production from the irradiated targets when the methilentilketon is used as the extragent. The pilot lot of 99mTc-pertechnetate was produced. The results of investigations show the compliance of the radiopharmaceutical parameters with the requirements of normative documents for the treatment preparations. The production of closed radiation sources with 192Ir is presented.
Keywords
References
Vorona P.M., Gritzay O.O., Kalchenko O.I., Kolotiy V.V., Advances of the Ukrainian school of neutron physics at the WWR-M reactor// 40 anniversary of neutron investi-gations at the WWR-M reactor: Proceedings of scientific conference INR NASU. – Kiev, 2000, pp.20-33.
Grinik E.U., Chirko L.I., WWR-M reactor and progress of radiation physics in Ukraine//ibid., pp.14-19.
Vorona P.M., Utilization of the WWR-M reactor for the radionuclide production//ibid., pp.48-55.
Khujaev S., Egamediev S. Kh., Vorona P.M. Radionu-clide Generators // Proc. of the 2-nd Ind. Conf. Current Problems in Nuclear Physics and Atomic Energy (June 9-15, 2008, Kyiv, Ukraine).- pp.740-742.
Vorona P.N., Razbudey V.F. Calculation-analytical in-vestigations of neutron-physical characteristics of the WWR-M nuclear reactor of INR of Ukraine // Proc. of the 2-nd Ind. Conf. Current Problems in Nuclear Physics and Atomic Energy ( June 9-15, 2008, Kyiv, Ukraine).- Book of Abstracts.- pp.70-71.
Vorona O.M., Razbudey V.F., Computation investiga-tions and analysis of characteristics of the WWR-M reactor as the neutron source for the scientific and applied tasks// Nuclear Physics and Power. .-2010.-Т.11. № 1.-С.
Solodyannikova O.I., Atamanyuk N.P., Levchenko V.P., Shevel V.N., Makeev S.S, Sukach G.G., The results of pre-clinical testing of the domestic 99mTc-pertechnetate// Ukrainian Radiology Journal 2007, v.15, pp315-325.
Zykov M.P., Romanovskiy V.N., Vester D.V et al., Ex-traction generator utilization for the radiopharmaceutical production on the base of 99Мо //Radiochemistry, 2001, v.43, pp.264-266.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.
"No endorsement" policy: Unless explicitly stated otherwise, the opinions, analyses, discussions, views and recommendations outlined in the articles published in the International Nuclear Safety Journal (INSJ) are solely those of their respective authors and not of the editors, owners or publishers of the INSJ.